Rebecca A. Clayton
Education
- Ph.D., Biology, 1991, The George Washington University
- M.S., Entomology, 1981, University of Connecticut
- B.S., Biology, 1978, Iowa State University
- B.A., English, 1978, Iowa State University
Teaching Experience
- 2006-present: Adjunct Faculty, Mountain State University, Spectrum Health Sciences Program.
- 2004-present: Substitute Teacher, Pocahontas County, West Virginia
- 2002-2006: Adult Basic Education Teacher, Pocahontas County, West Virginia
- 1988: Lecturer and laboratory instructor for an undergraduate course in introductory biology for science majors (one semester, GWU).
- 1987: Laboratory instructor for a graduate course in scanning electron microscopy (two semesters, GWU).
- 1978-1984: Laboratory instructor for undergraduate courses in introductory biology and entomology (six semesters, University of Connecticut).
Scientific Experience
- 1993-1999: Department of Bioinformatics, The Institute for Genomic Research
- 1992-1993: Research Associate Faculty, Department of Microbiology, University of Maryland
- 1990-1992: Postdoctoral fellow in molecular genetics, National Research Council, NIH Program at Food and Drug Administration, Center for Biologics Evaluation and Research.
- 1989 Curatorial assistant at the National Museum of Natural History, Systematic Entomology Laboratory, USDA.
- 1985 Research fellow at the National Zoological Park, Smithsonian Institution.
- 1982-1983 Research assistant in systematic entomology laboratory, University of Connecticut.
- 1977: Laboratory assistant, medical entomology laboratory, Iowa State University
Editorial Experience
- 1986: Technical editor for the International Life Sciences Institute/Nutrition Foundation.
- 1974 Proofreader, Creston News Advertiser, Creston, Iowa--a daily newspaper.
Publications
Heidelberg, J.F., Paulsen I.T., Nelson, K.E., Gaidos, E.J., Nelson, W.C., Read, T.D., Eisen, J.A., Seshadri, R., Ward, N., Methe, B., Clayton, R.A., Meyer, T., Tsapin, A., Scott, J., Beanan, M., Brinkac, L., Daugherty, S., DeBoy, R.T., Dodson, R.J., Durkin, A.S., Haft, D.H., Kolonay, J.F., Madupu, R., Peterson, J.D., Umayam, L.A., White, O., Wolf, A.M., Vamathevan, J., Weidman, J., Impraim, M., Lee, K., Berry, K., Lee, C., Mueller, J., Khouri, H., Gill, J., Utterback, T.R., McDonald, L.A., Feldblyum, T.V., Smith, H.O., Venter, J.C., Nealson, K.H., Fraser, C.M. Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis. Nat Biotechnol. 2002 Nov;20(11):1118-23.
DNA sequence of both chromosomes
of the cholera pathogen Vibrio cholerae Heidelberg, J.F.,
Eisen, J.A., Nelson, W.C., Clayton,R.A., Gwinn, M.L., Dodson,
R.J., Haft, D.H., Hickey, E.K., Peterson, J.D., Umayam, L., Gill,
S.R., Nelson, K.E., Read, T.D., Tettelin, H., Richardson, D.,
Ermolaeva, M.D., Vamathevan, J., Bass, S., Qin, H., Dragoi, I.,
Sellers, P., McDonald, L., Utterback, T., Fleishmann, R.D., Nierman,
W.C., White, O., Salzberg, S.L., Smith, H.O., Colwell, R.R.,
Mekalanos, J.J., Venter, J.C. and Fraser, C.M. Nature
406:477-483 (2000).
Identification of a Vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage. Wei Lin, Karla Jean Fullner, Rebecca Clayton, Jessica A. Sexton, Marc B. Rogers, Kerstin E. Calia, Stephen B. Calderwood, Claire Fraser, and John J. Mekalanos. Proc Natl Acad Sci U S A. 1999 February 2; 96(3): 1071-1076.
Evidence for lateral gene transfer between
Archaea and Bacteria from genome sequence of Thermotoga
maritima. Nelson, K.E., Clayton, R.A., Gill, S.R., Gwinn,
M.L., Dodson, R.J., Haft, D.H., Hickey, E.K., Peterson, J.D., Nelson,
W.C., Ketchum, K.A., Mcdonald, L., Utterback, T.R., Malek, J.A.,
Linher, K.D., Garrett, M.M., Stewart, A.R., Cotton, M.D., Pratt, M.S.,
Phillips, C.A., Richardson, D., Heidelberg, J., Sutton, G.G.,
Fleischmann, R.D., Eisen, J.A., White, O., Salzberg, S.L., Smith,
H.O., Venter, J.C. and Fraser, C.M. Nature 399, 323 - 329
(1999).
Findings emerging from complete microbial genome
sequences. Clayton, R.A., White, O., and Fraser,
C.M. Current Opinion in Microbiology, 1:562-566
(1998).
Chromosome 2 sequence of the human malaria parasite
Plasmodium falciparum. Gardner, M.J., Tettelin, H., Carucci, D.J.,
Cummings, L.M., Aravind, L., Koonin, E.V., Shallom, S., Mason, T., Yu,
K., Fujii, C., Pedersen, J., Shen, K., Jing, J., Schwartz, D.C.,
Pertea, M., Salzberg, S., Zhou, L., Sutton, G.G., Clayton,
R.A., White, O., Smith, H.O., Fraser, C.M., Adams, M.D., Venter, J.C.,
and Hoffman, S.L. Science, 282:1126-1132
(1998).
Complete genomic sequence of Treponema
pallidum, the syphilis spirochete. Fraser, C.M., Norris, S.J.,
Weinstock, G.M., White, O., Sutton, G., Clayton, R., Dodson,
R., Gwinn, M., Hickey, E., Ketchum, K.A, Sodergren, E., Hardham, J,
McLeod, M., Salzberg, S., Khalak, H., Weidman, J., Howell, J.K.,
Chidambaram, M., Utterback, T., McDonald, L., Artiach, P., Bowman, C.,
Garland, S., Fujii, C., Cotton, M.D., Horst, K., Roberts, K., Hatch,
B., Smith, H.O., and Venter, J.C. Science, 281: 375-388
(1998).
Genomic Sequence of the Lyme Disease Spirochaete,
Borrelia burgdorferi. Fraser, C.M., Casjens, S., Huang, W.M.,
Sutton, G.G., Clayton, R.A., Lathigra, R., White, O., Ketchum,
K.A., Dodson, R.,Hickey, E.K., Gwinn, M., Dougherty, B., Tomb, J.-F.,
Fleischmann,R.D., Richardson, D., Peterson, J., Kerlavage,
A.R.,Quackenbush, J., Salzberg, S., Hanson, M., van Vugt, R., Palmer,
N., Adams, M.D., Gocayne, J., Weidman, J., Utterback, T.,Wathey, L.,
McDonald, L., Artiach, P., Bowman, C., Garland, S., Fujii, C., Cotton,
M.D., Horst, K., Roberts, K., Hatch, B.,Smith, H.O., and Venter,
J.C. Nature 390, 580-586 (1997).
The Complete Genome
Sequence of the Hyperthermophilic, Sulphate-Reducing Archaeon
Archaeoglobus fulgidus. Klenk, H.P., Clayton,
R.A., Tomb, J.-F., White, O., Nelson, K.E., Ketchum, K.A., Dodson,
R.J., Gwinn, M., Hickey, E.K.,Peterson, J.D., Richardson, D.L.,
Kerlavage, A.R, Graham, D.E., Kyrpides, N.C., Fleischmann, R.D.,
Quackenbush, J., Lee,N.H., Sutton, G.G., Gill, S., Kirkness, E.F.,
Dougherty, B.A., McKenney, K., Adams, M.D., Loftus, B., Peterson, S.,
Reich,C.I., McNeil, L.K., Badger, J.H., Glodek, A., Zhou, L.,
Overbeek, R., Gocayne, J.D., Weidman, J.F., McDonald, L.,Utterback,
T., Cotton, M.D., Spriggs, T., Artiach, P., Kaine, B.P., Sykes, S.M.,
Sadow, P.W., D'Andrea, K.P., Bowman, C., Fujii, C., Garland, S.A.,
Mason, T.M., Olsen, G.J., Fraser, C.M., Smith, H.O., Woese, C.R., and
Venter, J.C., Nature 390, 364-370 (1997).
Clayton,
R.A., White, O., Ketchum, K.A., and Venter, J.C. 1997. The first
genome from the third domain of life. Nature
387:459-462.
The complete genome sequence of the gastric
pathogen Helicobacter pylori. Tomb, J.-F., White, O.,
Kerlavage, A.R., Clayton, R.A., Sutton, G.G., Fleischmann,
R.D., Ketchum, K., Klenk, H.-P., Gill, S.R., Dougherty, B.A., Nelson,
K.E., Quackenbush, J., Zhou, L., Kirkness, E.F., Peterson, S., Loftus,
B., Richardson, D., Dodson, R., Khalak, H.G.,Glodek, A., McKenney, K.,
Fitzgerald, L.M., Lee, N., Adams,M.D., Hickey, E.K., Berk., D.E.,
Gocayne, J.D., Utterback, T.R., Peterson, J.D., Kelley, J.M., Cotton,
M.D., Weidman, J.F., Fugii, C., Bowman, C., Watthey, L., Wallin, E.,
Borodovsky, M., Hayes, W.S., Karp, P., Smith, H.O., Fraser, C.M., and
Venter, J.C. Nature. (1997).
Bult, C.J., J.A. Blake,
M.D. Adams, O. White, G.G. Sutton, R.A. Clayton,
A.R. Kerlavage, C. Fields, and JC. Venter. 1997. The Impact of Rapid
Gene Discovery Technology on Studies of Evolution and
Biodiversity. In: Biodiversity II: Understanding and Protecting Our
Biological Resources, M.L. Reaka-Kudla, D.E. Wilson and E.O. Wilson,
eds. Joseph Henry Press.
Colwell, R.R., R.A. Clayton,
B.A. Ortiz-Conde, D Jacobs and E. Russek-Cohen. 1996. The Microbial
Species Concept and Biodiversity. In: Biodiversity of Microorganisms
and its Relevance, D. Hawksworth, D. Allsopp and R.R. Colwell,
eds. CAB International
Publishers.
Bult,C.J., White,O.,
Olsen,G.J., Zhou,L., Fleischmann,R.D., Sutton,G.G., Blake,J.A.,
FitzGerald,L.M., Clayton,R.A., Gocayne,J.D., Kerlavage,A.R.,
Dougherty,B.A., Tomb,J.-F., Adams,M.D., Reich,C.I., Overbeek,R.,
Kirkness,E.F., Weinstock,K.G., Merrick,J.M., Glodek,A.,Scott,J.L.,
Geoghagen,N.S.M.,Weidman,J.F., Fuhrmann,J.L., Presley,E.A., Nguyen,D.,
Utterback,T.R., Kelley,J.M., Peterson,J.D., Sadow,P.W., Hanna,M.C.,
Cotton,M.D., Hurst,M.A., Roberts,K.M., Kaine,B.P., Borodovsky,M.,
Klenk,H.-P., Fraser,C.M., Smith,H.O., Woese,C.R. and
Venter,J.C. 1996. Complete genome sequence of the methanogenic
archeon, Methanococcus jannaschii. Science
273:1058-1073.
Clayton, R.A., G. Sutton, P.S. Hinkle,
C. Bult, and C. Fields. 1995. Intraspecific variation in small-subunit
rRNA sequences in GenBank: Why single sequences may not
adequatelyrepresent prokaryotic
taxa. Int. J. System. Bacteriol. 45(3):
595-599.
Fleischmann, R.D., M.D. Adams, O. White,
R.A. Clayton, E. Kirkness, A.R. Kerlavage, C.J. Bult,
J.-F. Tomb, B. Dougherty, J.M. Merrick, G. Sutton, W. FitzHugh,
C. Fields, J. Gocayne, J. Scott, R. Shirley, L.-I. Liu, A. Glodek,
J.M. Kelley, J.F. Weidman, Cheryl A. Phillips,T. Spriggs, E. Hedblom,
M.D. Cotton, T.R. Utterback, M.C. Hanna, D.T. Nguyen, D.M. Saudek,
R.C. Brandon, L.D. Fine, J. L. Fritchman, J.L. Fuhrmann,
N.S.M. Geoghagen, L.C. Gnehm, L.A. McDonald, K.V. Small, C.M. Fraser,
H.O. Smith, and J.C. Venter. 1995. Whole genome shotgun sequencing and
assembly of the Haemophilus influenzae Rd
genome. Science 269:496-512.
Fraser, C.M., J.D. Gocayne,
O. White, M.D. Adams, R.A. Clayton, R.D. Fleischmann,
C.J. Bult, A.R. Kerlavage, G. Sutton, J.M. Kelley, J.L. Fritchman,
J.F. Weidman, K.V. Small, M. Sandusky, J. Fuhrman, T.R. Utterback,
D.M. Saudek, C.A. Phillips, J.N. Merrick, J.-F. Tomb,B.A. Dougherty,
K.F. Pott, P.-C. Hu, T.S. Lucier, S.N. Peterson, H.O. Smith,
C.A. Hutchison III, and J.C. Venter. The Mycoplasma genitalium
genome sequence reveals a minimal gene complement. Science
270:397-403..
Adams, M.D., A.R. Kerlavage, R.D. Fleischmann,
R.A. Fuldner, C.J. Bult, N.H. Lee, E.F. Kirk ness, K.G. Wienstock,
J.D. Gocayne, O. White, G. Sutton, J.A. Blake, R.C. Brandon, M.-W
Chiu, R.A. Clayton...82 authors....C.A. Rosen, W.A. Haseltine,
C. Fields, C.M. Fraser, and J.C. Venter. 1995. Initial assessment of
human gene diversity and expression patterns based upon 52 million
basepairs of cDNA sequence. Nature
377(6547S):3-174.
Clayton, R.A. 1989. Preparation of
Miridae phalluses (Heteroptera) for scanning electron microscopy, with
a redescription of the Mirinae
vesica. Trans. Amer. Microsc. Soc. 108: 419-
423.